Brings about an effect on the {〜} in {〜にかかわる} is often something that is important or serious. However, there are also uses where it simply means related to
LR
命に関わる Is a set phrase "To be a matter of life or death"
LR
Such important / serious things that might be affected are frequently 命 life, 威信 prestige / dignity, 名誉 honour 〜生活〜 things to do with lifestyle 〜環境 environments.
LR
is this a formal version 関係?
dc
The opposite to this is にかかわらず which is 2級 grammar.