Ref # A Dictionary of Advanced Japanese Grammar p493
LR
NOUN ((or nominalized phrase)) + をものともせずに Sometimes the に is omitted
LR
X をものともせずに "lit., without making something out of X" means that one does something bravely and fearlessly in spite of existing, unfavorable circumstances.
LR
added a translation and some see also links. be nice to know subtelties between this and [nishiro]
dc
perhaps others are "despite" whereas this is a much stronger "in defiance of/against all odds" type phrase...
dc
I think it also means 'regardless'; behaving as though the obstacle or whatever isn't actually there.