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English
Conjunction
and yet, despite this, but even so, but even then, however, nevertheless, for all that, notwithstanding that

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Grammar
~なのに: but, although (contrast, surprising)
それなのに
Phrases
佐渡さんは魅力的な個性の持ち主なのに、その価値が分からず、自分を好まない。
Parts: さん (み) 魅力的 (みりょくてき) 個性 (こせい) 持ち主 (もちぬし) なのに 其の (その) 価値 (かち) 分かる (わかる) 自分 (じぶん) 好む (このむ)
Even though Sato has a nice personality, he doesn't know its value and doesn't like himself.