は
Particle, pronounced わ in modern Japanese
1. indicates sentence topic
2. indicates contrast with another option (stated or unstated)
3. adds emphasis
どんなに
Adverb
1. how, how much, to what extent
as どんなに...ても, どんなに...でも, etc.
2. no matter how (much), however
君は私がどんなに心配しているかを知らない。